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新(xīn)鮮出爐|免費下載類風濕關節炎發病機制信号通路圖

2022/8/9 15:35:08      點擊:

類風濕關節炎(Rheumatoid Arthritis,RA)是一種全身性、慢性炎症性疾病。雖然RA的确切原因尚未明确,但遺傳和環境因素都與RA的易感性改變有(yǒu)關。類風濕關節炎會反複持續激活先天和适應性免疫系統,随着時間的推移,會導緻免疫耐受失敗、自身抗體(tǐ)産(chǎn)生和炎症細胞因子過量産(chǎn)生。這反過來又(yòu)會導緻類風濕關節炎症,最終導緻永久性的、緻殘的軟骨和骨骼損傷。類風濕性關節炎患者也可(kě)能(néng)出現肺部和心髒的全身性炎症。

類風濕關節炎的發病機制是一個跨越數十年的複雜過程,涉及多(duō)種細胞類型和信号通路。CST信号通路圖展示了參與類風濕性關節炎發病機制的不同細胞類型如何相互作(zuò)用(yòng),并指出 RA 誘導分(fēn)子和 RA 抑制分(fēn)子,以及潛在的治療機制,包括能(néng)夠觀察類風濕性關節炎發病機制的細胞類型、信号通路和分(fēn)子的關鍵 CST 産(chǎn)品列表。

貨号

産(chǎn)品名(míng)稱

應用(yòng)

反應性

67824

ASC/TMS1 (D2W8U) Rabbit mAb (Mouse Specific)

W IP IHC-P IF-F IF-IC F

M

17507

ASC/TMS1 (D2W8U) Rabbit mAb (Mouse Specific) (Alexa Fluor® 488 Conjugate)

IF-IC F

M

2873

ATM (D2E2) Rabbit mAb

W

H M

98033

Caspase-1 (E4R8K) Rabbit mAb

W IHC-P

H

89332

Cleaved Caspase-1 (Asp296) (E2G2I) Rabbit mAb

W IP

M (R)

4199

Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb

W IP

H (Mk)

78588

CD3ε (E4T1B) XP® Rabbit mAb

W IP IHC-Bond IHC-P IF-F

M

85061

CD3ε (D7A6E™) XP® Rabbit mAb

W IP IHC-Bond IHC-P

H Mk

26582

CD3 (17A2) Rat mAb (redFluor™ 710 Conjugate)

IF-F F

M

48274

CD4 (EP204) Rabbit mAb

IHC-Bond IHC-P

H

25229

CD4 (D7D2Z) Rabbit mAb

W IHC-Bond IHC-P

M R

96127

CD4 (RM4-5) Rat mAb (FITC Conjugate)

IF-F F

M

98941

CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific)

W IHC-Bond IHC-P

M

85336

CD8α (D8A8Y) Rabbit mAb

W IP IHC-P F

H

64786

CD8α (2.43) Rat mAb (APC Conjugate)

IF-F F

M

86165

CD40 (E2Z7J) Rabbit mAb

W IP IHC-Bond IHC-P

M

40868

CD40 (D8W3N) Rabbit mAb

W IHC-Bond IHC-P

H

15094

CD40 Ligand (D5J9Y) Rabbit mAb

W IP IHC-P

H

13917

CD45 (Intracellular Domain) (D9M8I) XP® Rabbit mAb

W IP IHC-P IF-IC F

H Mk

98819

CD45 (D3F8Q) Rabbit mAb (BSA and Azide Free)

IHC-Bond IHC-P IF-F IF-IC

M

19581

CD45 (D3F8Q) Rabbit mAb (Alexa Fluor® 555 Conjugate)

IF-F IF-IC

M

72031

CD57 (HNK-1) Mouse mAb

IHC-Bond IHC-P IF-IC

H

72031

CD68 (D4B9C) XP® Rabbit mAb

IHC-P IF-IC F

H

97778

CD68 (E3O7V) Rabbit mAb

W IHC-Bond IHC-P IF-F IF-IC F

M

51644

CD68 (E3O7V) Rabbit mAb (Alexa Fluor® 488 Conjugate)

IF-F IF-IC F

M

24595

CD206/MRC1 (E6T5J) XP® Rabbit mAb

W IP IHC-Bond IHC-P IF-F

H M R Mk

59414

CD206/MRC1 (E6T5J) XP® Rabbit mAb (Alexa Fluor® 594 Conjugate)

IF-F

H M R

10137

Cleaved Gasdermin D (Asp276) (E3E3P) Rabbit mAb

W

M

36425

Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb

W IP IHC-P

H

12311

DNA-PKcs (3H6) Mouse mAb

W IHC-P IF-IC

H Mk

70076

F4/80 (D2S9R) XP® Rabbit mAb

W IP IHC-P

M

66562

FAP (E1V9V) Rabbit mAb

W IP IF-IC

H

39754

Gasdermin D (E9S1X) Rabbit mAb

W IP

H M R Hm

4814

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen)

W IP IHC-P IF-IC F

H M R Mk B Pg

7523

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (PE Conjugate)

F

H M R Mk B Pg

12703

IL-1β (D3U3E) Rabbit mAb

W IF-IC F

H

12242

IL-1β (3A6) Mouse mAb

W IHC-P

H M

12912

IL-6 (D5W4V) XP® Rabbit mAb (Mouse Specific)

W IP IF-IC F

M

13797

IL-6 (D5W4V) XP® Rabbit mAb (Mouse Specific) (PE Conjugate)

F

M

18935

IL-6Rα/CD126 (E5B3P) Rabbit mAb

W IP IF-IC F

H

3230

Jak2 (D2E12) XP® Rabbit mAb

W IP IHC-P

H M R (Hm) (Mk) (C) (X) (B) (Dg) (Pg) (Hr)

3776

Phospho-Jak2 (Tyr1007/1008) (C80C3) Rabbit mAb

W

H M R (Mk) (B)

63125

FastScan™ Phospho-Jak2 (Tyr1007/1008) ELISA Kit

ELISA

H M

68258

MHC Class II (LGII-612.14) Mouse mAb

W IP IHC-Bond IHC-P F

H

4847

Mre11 (31H4) Rabbit mAb

W IP IHC-P

H

4895

Mre11 Antibody

W IP IHC-P

H M R Mk

8242

NF-κB p65 (D14E12) XP® Rabbit mAb

W IP IHC-P IF-IC F ChIP ChIP-seq C&R

H M R Hm Mk Dg

3033

Phospho-NF-κB p65 (Ser536) (93H1) Rabbit mAb

W IP IF-IC F

H M R Hm Mk Pg (Dg)

4887

Phospho-NF-κB p65 (Ser536) (93H1) Rabbit mAb (Alexa Fluor® 647 Conjugate)

F

H M R Hm Mk Pg (Dg)

26981

Podoplanin (LpMab-12) Mouse mAb

IHC-P F

H

9139

Stat3 (124H6) Mouse mAb

W IP IHC-P IF-IC F ChIP

H M R Mk

9145

Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb

W IP IHC-Bond IHC-P IF-IC F ChIP ChIP-seq

H M R Mk (Hm) (B) (Pg) (Hr)

8119

Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (PE Conjugate)

F

H M R Mk (Hm) (B) (Pg) (Hr)

16242

FastScan™ Phospho-Stat3 (Ser727) ELISA Kit

ELISA

H M R Mk

11948

TNF-α (D2D4) XP® Rabbit mAb (Mouse Specific)

W IP IF-IC F

M

87509

TNF-α (D2D4) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate)

F

M

8184

TNF-α (D1G2) Rabbit mAb (IF/Flow Preferred)

W IP IF-IC F

H

96865

TNF-α (D1G2) Rabbit mAb (PE-Cy7® Conjugate)

F

H

13801

Thy1/CD90 (D3V8A) Rabbit mAb

W IHC-P

H M R


類風濕性關節炎發病機制和相關抗體(tǐ)信号通路圖,可(kě)用(yòng)于研究與自身免疫性疾病相關靶點。


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